Op-brai120190 1..14

نویسندگان

  • Elizabeth J. Coulthard
  • Rafal Bogacz
  • Shazia Javed
  • Lucy K. Mooney
  • Gillian Murphy
  • Sophie Keeley
  • Alan L. Whone
چکیده

1 Department of Neurology, Institute of Clinical Neurosciences, University of Bristol and North Bristol NHS Trust, Bristol, BS16 1LE, UK 2 Department of Computer Science, University of Bristol, Bristol, BS8 1UB, UK 3 Department of Neurosurgery, Institute of Clinical Neurosciences, University of Bristol and North Bristol NHS Trust, Bristol, BS16 1LE 4 Department of Neurosciences, North Bristol NHS Trust, Bristol, UK 5 Department of Clinical Neuropsychology, North Bristol NHS Trust, Bristol, BS16 1LE, UK

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Op-brai120190 3721..3734

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[Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies.

The nociceptin (NC)/orphanin FQ analog, [Arg(14),Lys(15)]NC, has been recently demonstrated to behave as a potent agonist at the human recombinant NC receptors (OP(4)). In this study, we evaluated the pharmacological profile of [Arg(14),Lys(15)]NC in vitro on the native OP(4) receptors expressed in isolated tissues and in vivo in the locomotor activity and the tail-withdrawal assays in mice. On...

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تاریخ انتشار 2012